Welcome to MTSviewer, a database of mitochondrial proteins integrating:


- MTS predictions
- MPP cleavage sites
- Genetic variants
- Pathogenicity predictions
- N-terminomics data
- Structural visualization using AlphaFold models

Using this platform, we have generated a list of disease-linked variants in protein MTS's and their predicted consequences as a resource for their functional characterization. Overall, MTSviewer is a platform that can be used to interrogate MTS mutations and their potential effects on import and proteolysis across the mitochondrial proteome.

Click on the MTSviewer tab and start interrogating your favorite protein(s) listed in the dropdown menu!



iMLP curves

 

                

                

                
Sequence

                

                

                

                  
Mutation List

                  

                    

                  

                

                

                

                  

                    
                      
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Cleavage Site Predictions

                  

                  
                    
MitoFates

                  
                  

                    

                  

                  

                  
                    
TargetP

                  
                  

                    

                  

                  

                  
                    
TPPred3

                  
                  

                    

                  

                

                

                

                  
                    
TopFind

                  
                  

                    

                      

                    

                  

                

              

              

              

                
                  
DeepMito

                
                

                  

                    

                  

                

                

              

              

                

              

            

          

        

        

          

            

          

        

        

          

            

          

        

        

          

            

            
          

        

        

          

            

            
To report bugs, comments, or to submit custom proteins to be added to MTSviewer, please e-mail: 

            
              
mtsviewer.docs@gmail.com

            
            
If you are requesting specific proteins to be added to MTSViewer, please attach a FASTA file of interest.

          

        

        

          

            

            
When using MTSviewer please cite: 

            
MTSviewer: a database to visualize mitochondrial targeting sequences, cleavage sites, and mutations on protein structures
Andrew N. Bayne, Jing Dong, Saeid Amiri, Sali M.K. Farhan, Jean-Francois Trempe (2023)
PLOS ONE 18(4): e0284541.
DOI: https://doi.org/10.1371/journal.pone.0284541